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Swanson Ultra

High-Potency SAMe

4.6 out of 5 173 Customer Reviews
Customer Favorite

High-Potency SAMe

Item: SWU218

  • SAMe works to promote both joint mobility and emotional stability



  • This ultra-potent supplement is backed by more than 20 years of research



  • A powerful precursor to glutathione, a potent cellular antioxidant believed to be a "master nutrient" for longevity



  • Delivers 400 mg of SAMe per tablet


400 mg 30 Tabs
Tabs Size: S

$17.99
MSRP $25.49
Save 29%
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Featured review

"I have tried every other mood enhancing supplement out there but nothing else works like sam-e. ... It is so expensive in the stores here but very affordable through Swansonvitamins." ~product review by SuperNova

See all reviews

Supplement Facts

Serving Size 1 Tablet

  Amount Per Serving % Daily Value
SAMe (S-Adenosyl L-Methionine)(from 800 mg S-adenosyl-L-methionine tosylate disulfate) 400 mg *

*Daily Value not established.

Other ingredients: Microcrystalline cellulose (plant fiber), croscarmellose sodium, ascorbic acid, citric acid, silica, ascorbyl palmitate, enteric coating [methacrylic acid copolymer, hydroxypropyl cellulose, hydroxypropyl methylcellulose, propylene glycol, calcium carbonate, riboflavin (colorant)].

Suggested Use: As a dietary supplement, take one tablet one to four times per day with water.

Enteric-coated to enhance stability.

WARNING: Consult your healthcare provider before use if you are pregnant or nursing, taking antidepressant medication or if you have bipolar disorder.

Relative Size

Printable Size Guide

Shipping Weight

.13 lbs

  • SAMe works to promote both joint mobility and emotional stability



  • This ultra-potent supplement is backed by more than 20 years of research



  • A powerful precursor to glutathione, a potent cellular antioxidant believed to be a "master nutrient" for longevity



  • Delivers 400 mg of SAMe per tablet


Promote emotional wellness and joint mobility with Swanson SAMe 400 mg! SAMe (s-adenosyl methionine) is a double-duty nutrient that promotes healthy joint function and vital neurotransmitter production. Each convenient tablet delivers 400 mg of SAMe support. Recently, SAMe has been acknowledged as a powerful precursor to glutathione, a potent cellular antioxidant believed to be a "master nutrient" for longevity. Delivered in enteric-coated tablets for maximum bioavailability.

Swanson Ultra High-Potency SAMe Reviews

Summary of Customer Ratings & Reviews

Customer Ratings & Reviews

High-Potency SAMe is rated 4.6 out of 5 by 173.
Rated 5 out of 5 by from This supplement works! I've heard much about SAMe over the years but never have used the product. I was quite surprised when I tried it over the past few months. It really improved my quality of mood plus helping with daily walking and hiking. This is something that works well for me. The quality and smoothness of the tablets enable easy swallowing.
Date published: 2017-04-27
Rated 3 out of 5 by from I like another brand better I have bought this before and didn't think it worked as well as another brand that I usually buy but decided to try it again because it is cheaper. This time I noticed a strange taste when I take the tablets. It has been fairly effective and it is convenient to have the bubble pack which can be kept at room temperature. With that said, I still like the Now brand better so I'll just stick with it.
Date published: 2017-03-13
Rated 4 out of 5 by from SAMe keeps me happy! I am glad to have 3 in 1 pill, for mood, liver and joints, Also the packaging on these is very good!
Date published: 2016-12-18
Rated 5 out of 5 by from Walking is enjoyable again. This product works for me in two ways; lifting my discomfort with exercise and lifting my mood too. I recommend ordering in cool weather as product sits for a long time in hot trucks during slow shipping.
Date published: 2016-09-19
Rated 5 out of 5 by from Mood boost I started taking this last week and noticed a boost in my mood right away.
Date published: 2016-07-19
Rated 5 out of 5 by from Every Morning I find Swanson has the best price for sam-e400mg. I have been taking this for years every morning on an empty stomach. It has helped me with mood stability. With this dosage I only need to take 1 tablet. which is kept fresh by being individually foil covered.
Date published: 2016-06-26
Rated 5 out of 5 by from has helped me with positive feelings Taking Swanson SAMe has helped me to feel better mentally. Also with my skeletal system. It takes a while to work but I know on some people it works faster.The thing is you have to be consistent in taking SAMe. daily. For a while I was thinking that it was not working but then my better days are more frequent than my bad days.
Date published: 2016-02-27
Rated 5 out of 5 by from Great product....Great price my naturopath recommended Sam e.....I found that most brands are way too expensive.....Swanson is a great price and the supplement works great
Date published: 2016-01-20
Rated 5 out of 5 by from consistantly cheaper Great product that does what it claims and is consistently cheaper than retail.
Date published: 2015-07-12
Rated 4 out of 5 by from My wife has been taking this product for years. One tablet per day, in the am. We recently decided to cut back to one half a tablet per day and may eventually discontinue the use of the SAME. Just not sure that it's something that's beneficial.
Date published: 2015-03-07
Rated 5 out of 5 by from Great Help in time of need I use this when I'm having challenging days--it really helps to settle me so that I'm not bothered at all by what's happening around me.
Date published: 2014-12-24
Rated 2 out of 5 by from Extra Strength Tabs Way too Large I had been taking these for several years with no complaints. Within the past six months or so, however, the tablets have changed. They used to be smooth and oval, now they are very large and rectangular. I just can't get them down with that size and shape. Also, a few tablets in one box were soft, like chewing gum, which for this product is unacceptable as they are enteric coated and not supposed to dissolve in the stomach. Swanson customer service has been EXCELLENT in addressing these issues with me over the phone, by the way. If you have problems swallowing really large pills, I would definitely not recommend these. I'll be switching exclusively to the regular strength tablets from now on.
Date published: 2014-10-15
Rated 5 out of 5 by from Great product Very good quality and best price I've found.
Date published: 2014-08-18
Rated 5 out of 5 by from Helps a lot This product helps my mood and my joints - how cool is that?? I've been taking it for awhile and Swanson's price is better than any I've seen. I feel better and my wallet feels better : + }
Date published: 2014-08-17
Rated 5 out of 5 by from Helps my old bones & cranky ways My wife said here you go old man ... take these!
Date published: 2014-05-19
Rated 5 out of 5 by from Very Effective I have used Sam-E for quite a while now, and it is wonderful! I can definitely feel a difference in my joints and mood when I use it regularly. Swanson's seems to be the best quality - most effective - that I've found. I've tried other brands nominally less expensive, but none work as well as these, and the bubble cards make it easy to travel with. Thank you, Swanson, for making such an effective and affordable product!
Date published: 2014-02-26
Rated 5 out of 5 by from WORKS & DOESN'T BREAK THE BANK Gotta love the mg too.....LESS PILLS TO TAKE....WORKS GREAT
Date published: 2014-02-01
Rated 5 out of 5 by from Good Product! This product helps my mood. It seems to take the "edge" off when I can't cope very well. I do take it every day and I take another if it is a especially difficult day. I looked up the ingredients and you do have to check what medications it might interact with. I am very pleased with this and I would recommend it
Date published: 2014-01-12
Rated 5 out of 5 by from great stuff! I would recommend this product to anyone.
Date published: 2013-12-08
Rated 5 out of 5 by from Multipurpose Helper This product has been of the utmost help to me for exactly how it is advertised. Swanson has the best price & trust me, I have checked every source available! When you live on a fixed budget, this is of significant value. Swanson has dependable service whether you order on-line or by phone, I feel products are reliably consistent with good quality control. I am a customer of 10+ yrs. & will continue to be after making the mistake of ordering from someone else. CSRs should all follow the training of Swanson. Always a pleasant experience here.
Date published: 2013-12-07
Rated 3 out of 5 by from Same The price and quality was good
Date published: 2013-11-25
Rated 5 out of 5 by from Feeling good Have felt this supplement serves me well. Great quality.
Date published: 2013-11-14
Rated 5 out of 5 by from Works For Me I have been using this for 5 months and will continue to use because it is working well for me!
Date published: 2013-11-11
Rated 5 out of 5 by from excellent product I first bought sam-e from one of the quality, extremely high priced vitamin brands... then switched to Swansons. Can't tell the difference... except in my wallet.
Date published: 2013-10-30
Rated 5 out of 5 by from Great Product I have been using this product for several months now and can't see going to any other brand. Great product.
Date published: 2013-10-28
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Our lab evaluates every product to make sure it’s compliant with strict standards and government regulations, and we fully believe in and stand behind our products. If you’re dissatisfied for any reason, we’ll give you a full refund and pay return shipping.

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400 mg 30 Tabs
Tabs Size: S

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*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
For our website and catalog, the MSRP is the "Manufacturer's Suggested Retail Price." The MSRP is understood to mean the price at which a manufacturer will recommend a retailer sell a product for in stores, on the internet, or in catalogs. The MSRP of National brand items are dictated to Swanson by each manufacturer. For Swanson brand items, the MSRP is calculated based on a varying percentage above the product's base price.
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