Cetyl myristoleate (CMO) is the common name for cis-9-cetyl myristoleate, a fatty acid ester consisting of cetyl alcohol and myristoleic acid. It occurs naturally in certain rodents such as beavers and Swiss albino mice. Discovered in 1964 by Harry W. Diehl, a researcher at the National Institutes of Health, CMO was virtually unknown to the scientific community until 1976. Although CMO was originally derived from mice, it is now commonly produced by combining cetyl alcohol with myristoleic acid derived from vegetable sources. A waxy substance at room temperature, CMO is a pale-yellow, oily substance at body temperature. CMO is available as a dietary supplement in tablet, capsule, and softgel forms. It is also available in creams and lotions for topical application.
The usual dosage recommendation for CMO is 400 to 500 mg per day for 30 days. It is often recommended that CMO be used in conjunction with cartilage-nourishing supplements such as glucosamine sulfate. CMO has no known toxicity and is generally well tolerated; however, it may produce mild burping in some individuals.