A mug of apple cider vinegar next to some dandelions on a table
Cleanse and Detox
Top Supplements for Detoxing the Body
Swanson Staff • May 16, 2025

Top Supplements for Detoxing the Body

Exposure to pollutants, processed foods and stress can strain the liver, gut and immune system—the body’s natural detox network. While these systems work hard to eliminate toxins, natural supplements can offer added support by enhancing their function and promoting overall balance in the body.

Why Consider Supplements for Detoxification?

Environmental toxins, poor diets and chronic stress can overload our natural detox systems. The liver and kidneys filter toxins, the gut eliminates waste and the immune system defends against harmful invaders. When these systems become compromised, it can affect energy, digestion and immune health.

Natural detox supplements like milk thistle, turmeric, probiotics and fiber can help protect liver cells, support gut health and boost immune function. These nutrients collaborate to improve the body’s detox capacity and resilience against daily stressors.

Best Supplements to Support Your Body’s Natural Detox 

Milk Thistle

Milk thistle’s active compound, silymarin, helps protect liver cells from damage caused by toxins, alcohol and pollutants.1 Silymarin also supports the regeneration of liver tissue and enhances the production of glutathione (a critical antioxidant that plays a key role in the body’s detox processes). By strengthening liver function, Swanson Premium Milk Thistle can help the body more efficiently process and eliminate harmful substances, making it a valuable ally in natural detox support.

Dandelion Root

Traditionally used for liver, kidney and digestive health, dandelion root acts as a gentle diuretic, helping the body eliminate excess water and toxins through the kidneys. Dandelion root also facilitates the removal of pathogens in the gastrointestinal tract.2  Bioactive compounds found in dandelion root may protect against free radical damage and maintain healthy immune function. Using Swanson Dandelion Root Capsules as a liver detox supplement can help stimulate bile production to support liver detoxification. 

NAC (N-Acetyl Cysteine)

NAC is a powerful antioxidant and a precursor to glutathione, one of the body’s most important detox molecules. By boosting glutathione levels, NAC helps protect the liver from oxidative stressors and supports the breakdown and removal of toxins.3 It’s also known for supporting respiratory and immune health, making it a versatile supplement for overall wellness.

Probiotics

Probiotics are beneficial bacteria that help maintain a healthy balance in the gut microbiome. A well-balanced gut flora aids digestion, supports the immune system, and help protect the integrity of the gut barrier increasing mucus production and strengthening tight junctions between gut cells.4 Swanson Probiotic Supplements can promote regular bowel movements, bolster gut immunity and support the gut barrier.

Glutathione

Often called the "master antioxidant," glutathione is critical for neutralizing free radicals and supporting the liver’s detoxification pathways. It helps to bind toxins, including heavy metals, and facilitates their elimination from the body.5 While the body produces glutathione naturally, levels can decrease due to stress, aging and toxin exposure. Supplementing Swanson Maximum Strength Glutathione can help restore balance and boost the body’s detox capacity.

Fiber Supplements

Dietary fiber is essential for digestive health and effective detoxification. It helps bind waste and toxins in the digestive tract and supports regular bowel movements to ensure these substances are efficiently removed from the body. Soluble fibers like psyllium husk or inulin can also help nourish beneficial gut bacteria. Swanson Premium Psyllium Husk fiber supplements are a convenient way to boost your fiber intake and gut health.

Turmeric

Turmeric, and its active compound curcumin, offers powerful antioxidant and immune-system modulating actions that help support liver function and promote the body’s natural detox processes.6 Curcumin stimulates bile production, which aids digestion and the breakdown of fat-soluble toxins. It also supports liver health and helps the body maintain a balanced, healthy response to everyday stressors. Adding Swanson Curcumin Complex to your immune support and detox regimen may help protect tissues from oxidative pressures and enhance the body's ability to cleanse itself naturally.

Tips for Choosing Safe and Effective Detox Supplements 

With so many detox supplements on the market, it’s important to choose products that are effective and safe, and high quality. Here are some key tips to help you select the best supplements for detox and integrate them wisely into your wellness routine:

1. Prioritize Purity and Quality

 Look for detox supplements made with clean, natural ingredients and free from unnecessary additives, fillers or artificial colors. Check for labels that indicate non-GMO, organic or allergen-free formulas, especially if you have dietary restrictions or sensitivities.

2. Choose Third-Party Tested Products

Reputable brands often have their supplements independently tested by third-party laboratories for quality, potency and purity. Look for certifications from organizations like NSF, USP or ConsumerLab.

3. Buy From Trusted Brands

 Stick with established supplement companies with a history of transparency, strong reviews and good manufacturing practices (GMP) certification. 

4. Integrate Gradually and Monitor Your Body’s Response

Start with one supplement at a time to assess how your body responds. Begin with a lower dose, especially if you're new to body cleanse supplements and slowly increase as needed based on label instructions or your healthcare provider’s guidance.

5. Pair Supplements with Healthy Lifestyle Habits

Detox supplements work best when paired with a supportive lifestyle. Drink plenty of water, eat a balanced diet, exercise regularly and prioritize sleep to enhance the natural detoxification process and avoid overburdening your system.

6. Talk to a Healthcare Professional

Before starting any new supplement, it’s best to consult with a doctor, naturopath or registered dietitian to ensure safety and compatibility with your current routine.

A Balanced Approach to Detoxification

Supplements can support your body’s natural detox systems, but they’re most effective when paired with healthy habits. A nutrient-rich diet, hydration, exercise and stress management are essential. When used thoughtfully, high-quality natural detox supplements can enhance your body’s natural cleansing processes and lay the foundation for long-term wellness.

You be well, now.

Swanson

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Sources

  1. Abenavoli L, et al. Phytother Res. 2010 Oct;24(10):1423-32.  Read source  
  2. Wirngo, F. E., et al. (2016). The Review of Diabetic Studies : RDS13(2-3), 113–131. Read source
  3. V Mokhtari, Parvaneh Afsharian, et al. Cell Journal. Read source
  4. P Średnicka, E Juszczuk-Kubiak, et al. Food and Chemical Toxicology. Read source
  5. Ketterer, B., et al. (1983). Environmental Health Perspectives49, 59–69. Read source
  6. Peng Y., et al. Drug Des Devel Ther. 2021 Nov 2;15:4503-4525. Read source