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Item:  SWU217

  • Works to promote both joint mobility and emotional stability*

  • This ultra-potent supplement is backed by over 20 years of research

  • A powerful precursor to glutathione, a potent cellular antioxidant believed to be a "master nutrient" for longevity

  • 60 count blister pack

200 mg 60 Tabs
Tabs Size: L

Now $16.64
Extra 10% Off
Was $18.49
MSRP $26.49
Yes! I want 10% off and free shipping over $50 on my next automatic shipment of this item.  days. Learn more
In Stock

Supplement Facts

Serving Size 2 Tablets

Servings Per Container 30

  Amount Per Serving % Daily Value
SAMe (S-Adenosyl L-Methionine)(from 800 mg S-adenosyl-L-methionine tosylate disulfate) 400 mg *

*Daily Value not established.

Other ingredients: Microcrystalline cellulose (plant fiber), croscarmellose sodium, ascorbic acid, citric acid, silica, ascorbyl palmitate, enteric coating [methacrylic acid copolymer, hydroxypropyl cellulose, hydroxypropyl methylcellulose, propylene glycol, calcium carbonate, riboflavin (colorant)].

Suggested Use: As a dietary supplement, take two tablets one to four times per day with water.

Enteric coated to enhance stability.

WARNING: Consult your healthcare provider before use if you are pregnant or nursing, taking antidepressant medication or if you have bipolar disorder.

Relative Size

Printable Size Guide

Shipping Weight

.16 lbs

  • Works to promote both joint mobility and emotional stability*

  • This ultra-potent supplement is backed by over 20 years of research

  • A powerful precursor to glutathione, a potent cellular antioxidant believed to be a "master nutrient" for longevity

  • 60 count blister pack

Get effective nutritional support for emotional wellness and joint mobility with Swanson SAMe.* A dietary supplement without equal, SAMe (s-adenosyl methionine) is a double- duty nutrient that promotes healthy joint function and vital neurotransmitter production.* Each convenient tablet delivers 200 mg of SAMe support. Recently, SAMe has been acknowledged as a powerful precursor to glutathione, a potent cellular antioxidant believed to be a "master nutrient" for longevity.* Delivered in enteric- coated tablets for maximum bioavailability.

Swanson Ultra SAMe Reviews

Summary of Customer Ratings & Reviews

Customer Ratings & Reviews

SAMe is rated 4.6 out of 5 by 83.
Rated 5 out of 5 by from Good Results I tried this product for the first time because of what others have said about SAM-E. I did not expect the result I experienced! This supplement has performed a very satisfying daily change in mood. Note that I take a lot of supplements daily and feel very good doing so over the years. Could another supplement do anything more? To notice such a positive change is why I am impressed with this product.
Date published: 2017-02-16
Rated 5 out of 5 by from Same This product has really help me calm down when I have gotten myself into a stressful situation. All natural no side effects. Will definitely order again.
Date published: 2016-09-12
Rated 5 out of 5 by from Benefits to me and does as it is designed to do. II did a lot of reading on this product and decided to get the 200 mg rather than the 400 mg to have less chance of the 400 mg being too high. I did go ahead and take 2 200 mg tablets right away, however, and with no adverse effects. Also, the 200 mg physical size is "large" enough for me, and easier to take. I believe that this item is beneficial to me.
Date published: 2015-12-15
Rated 5 out of 5 by from stay happy keep happy you can over do the stay happy chemistry in your body, but a little goes a long way. Keep things in a even keel.
Date published: 2015-12-07
Rated 2 out of 5 by from Disappointed I, too, switched to the Swanson brand of SAM-e and am not happy with it! 1/ The pills are gigantic and stick in your throat 2/ They contain ingredients I don't want to ingest 3/ They smell and taste AWFUL, long after taking. 4/ They don't dissolve like the other brand I purchased before - after taking this Swanson brand, my husband suddenly had stomach issues and had to burp - and out came residue from the pill! We have always taken SAM-e on an empty stomach, so I know it was this pill - we've not had any trouble with the other brand. It's very seldom I've been disappointed with Swanson brand products, but I had to share this.
Date published: 2015-09-29
Rated 1 out of 5 by from not effective I purchased these Swanson brand Sam-E. Due to the pricing. They seem to have about half the dosage as claimed compared to the national brands such as Best Naturals. I have noticed the lack of efficacy in the Swanson brands and think in the future I will just stick with the national branded items as they have higher quality control.
Date published: 2015-09-12
Rated 5 out of 5 by from Another Great SWANSON's Product I take SAMe for my own personal reasons, and have for many years! In addition, I can tell you specifically that I have been a loyal customer of SWANSON's since 1999, they rank 99.99% in my book for quality and service, and I would recommend SWANSON's to all!
Date published: 2015-05-04
Rated 5 out of 5 by from samE to the rescue i appreciate the smaller dosage available via swanson ... if i want to double up it is my choice
Date published: 2015-03-05
Rated 3 out of 5 by from not satisfied I'd been using Costco's SAMe when I changed over to Swanson's. I immediately noticed a drop in effectiveness from the one day to next. Seemed I had to take twice the dose for a still unsatisfying effect. It did make me very drowsy, such that I could take it if I woke up early and would fall back into a deep sleep. Oddly, it didn't make me drowsy during the day...Overall, I prefer the Costco. Don't know why it'd be so different?
Date published: 2014-12-24
Rated 5 out of 5 by from Mood Help I purchased this and a full spectrum light bulb for my reading lamp and have noticed my mood improved in about 1 month. I took one a day on an empty stomach (no upset) and when I stopped taking it, I noticed a difference. Ordered more immediately. So happy this works for me.
Date published: 2014-11-08
Rated 5 out of 5 by from Effective for Me! I began by taking one 200mg tablet/day for one week, then upped to 2/day. By the end of week two, I noticed a marked improvement in my mood and overall feeling of well-being. It really took the edge off and helped me to cope with a personal crisis.
Date published: 2014-07-13
Rated 5 out of 5 by from Best Price Ever.. My husband was told by his Doctor to start taking this product. We saw the same product at one of the store's Dr. recommended. I checked your website and was so pleased with your price. You saved us a lot and my husband is a believer about why I shop Swanson's regularly.
Date published: 2014-07-02
Rated 1 out of 5 by from Good product but terrible packaging The tablets are in a foil blister wrap. Many of the tablets come out with a piece of foil stuck into it. Because I feel that foil isn't good to ingest, I have thrown many of the tablets away. I am very disappointed!
Date published: 2014-06-09
Rated 5 out of 5 by from Effective & gentle I have tried 5-HTP, St. John's Wort and most recently SAM-E to boost my mood and be more social. So far, SAM-E works the best of the three. SAM-E acts more gradually and the effects persist for days. In contrast to 5-HTP little acute effects are noticeable upon ingestion. I feel best on 2nd or 3rd day after taking it. it is important to note that recommended dosage is extremely high. Try taking 1 tablet a week if you have never taken this before.
Date published: 2014-02-05
Rated 5 out of 5 by from Thanks, Swansons! I have used Sam-e for years, and Swanson's version is the lowest-priced I've been able to find. Works great!
Date published: 2013-12-30
Rated 5 out of 5 by from Great product Great product which I use for mood support. I'm so glad my doctor told me about it. It is also a much better price than the name brand. Thank you, Swanson!!
Date published: 2013-12-19
Rated 5 out of 5 by from SamE Excellent product at an excellent price.
Date published: 2013-12-14
Rated 4 out of 5 by from Good Deal This was my first time using this product and was very pleased with the results. Took two tablets before breakfast and two more later in the day. The result was quite noticeable. Like it says on the box "Emotional Wellness".
Date published: 2013-12-14
Rated 5 out of 5 by from Great product I've been using SAMe for a while now (different brand) and really can tell a difference when I take it. I just switched over to getting it from Swanson and have been very pleased with the quality and price. I will definitely reorder.
Date published: 2013-12-09
Rated 4 out of 5 by from seems to work so far so good..will tell better in the long run..
Date published: 2013-12-08
Rated 5 out of 5 by from I actually see a difference I had to take this for about 30 days before I saw a difference. I started with 400 a day for about 3 months but find that 200 a day oes the trick. I'm glad they package these in foil packs because I've read it's not a very stable product otherwise. I've also read that it's very important to take this with B vitamins which I do.
Date published: 2013-12-06
Rated 5 out of 5 by from Great product. Works like it should.
Date published: 2013-12-04
Rated 5 out of 5 by from Well-Being I began taking a doctor-suggested dose of 200 mg three times a day and within the first week noticed that I was generally feeling better. Swanson's SAM-e is priced right and packaged conveniently.
Date published: 2013-11-14
Rated 5 out of 5 by from Recommended by my sister This supplement was recommended and I like it better than any I've tried. Blister pack is easy and maintains freshness
Date published: 2013-11-07
Rated 5 out of 5 by from Great Value This is an excellent value for this high quality product.
Date published: 2013-10-30
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