No Thanks

Your 10% Off Promo Code is on the Way! Thanks for signing up for emails.

You're now signed up to receive exclusive deals and savings opportunities!

Thanks again for connecting with us. Keep an eye on your inbox — your first coupon is on its way!

Thank You! This email address is already signed up

You are signed up for the following:

  • Offers
  • Recipes
  • E-Newsletter
  • Updates & Reminders

Thank you for your interest and be assured that you will continue to receive our emails at this address.

Look for your next communication from us within the next week.

Oops!

We are having trouble processing your request.

Our apologies!

Please try again later.

Customers Also Viewed

Supplement Facts

Serving Size 1 Tablet

Servings Per Container 30

  Amount Per Serving % Daily Value
S-Adenosyl Methionine(from 800 mg of SAMe tosylate disulfate) 400 mg

† Daily Value not established.

Other Ingredients: Cellulose, glyceryl behenate, magnesium stearate (vegetable source), silicon dioxide, mannitol and sodium starch glycolate. Enteric coating consists of modified cellulose, triethyl citrate, magnesium silicate and riboflavin.

USAGE: Take 1 tablet per day on an empty stomach or as directed by your qualified health care professional.

WARNING: Individuals using prescribed medications such as antidepressants, including Selective Serotonin Re-Uptake Inhibitors (SSRIs) and MAO Inhibitors should consult a physician before using this product. Individuals with Parkinson's disease, bi-polar disorder or manic depression should not use SAMe. Do not use if pregnant or nursing. Do not exceed recommended intake. May cause gastrointestinal upset in some persons. If you experience discomfort, discontinue use.

Jarrow Formulas® SAMe 400 is foil blister-packed to maximize stability and safety. DO NOT use if outer seal of blister pack is broken.

Store in a cool, dry place.

Keep out of the reach of children.

  • Suitable for vegetarians/vegans.
  • No wheat, no gluten, no soybeans, no dairy, no egg, no fish/shellfish, no peanuts/tree nuts.
  • Enteric-Coated Tablets
  • GLUTEN FREE
  • vegan
  • Supports mood and brain function



  • Helps detoxify the liver



  • Promotes healthy connective tissue


SAMe (S-Adenosylmethionine) is an amino acid derivative that has undergone dozens of trials involving thousands of patients and has been clinically proven to benefit brain and joint function. Found in all living cells, SAMe is also called activated methionine (an essential amino acid) since it is formed by the combining of ATP with methionine. SAMe 400 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product. It is made naturally by microbiological fermentation and then specially processed to preserve 68-80% (S,S) SAMe, the highest active level available.

Terms and Ingredient Definitions

Shipping Weight: .14 lbs

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

MSRP: $39.95

For our website and catalog, the MSRP is the "Manufacturer's Suggested Retail Price." The MSRP is understood to mean the price at which a manufacturer will recommend a retailer sell a product for in stores, on the internet, or in catalogs. The MSRP of National brand items are dictated to Swanson by each manufacturer. For Swanson brand items, the MSRP is calculated based on a varying percentage above the product's base price.

Rated 5 out of 5 by from Sam-e I purchased this and have found that the quality of this product is exactly like a product that cost so much more. Will reorder this in the future.
Date published: 2019-02-19
Rated 3 out of 5 by from I really can't tell if this product is doing anything or not. Maybe it takes a few months as sometimes supplements need. I will try it again for the fourth time.
Date published: 2015-04-15
Rated 5 out of 5 by from Great Product I have tried various brands of SAMe in the past. I find this brand to be the most effective for me.. Its quite expensive but worth the extra dollars. Give it a shot and see if you like
Date published: 2014-05-15
Rated 5 out of 5 by from SAM-e My stepfather told me about SAM-e many years ago. I've been using SAM-e 400 ever since. I like the bubble-pack style packaging - makes dosing easier and keeps the tablets whole.
Date published: 2014-02-17
Rated 5 out of 5 by from great product This product works great for me and the price is really good. (40.00 retail at local store)
Date published: 2013-06-24
  • y_2019, m_12, d_13, h_13
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.3
  • cp_1, bvpage1
  • co_hasreviews, tv_2, tr_20
  • loc_en_US, sid_JR041, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_swansonhealth
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getReviews, 11ms
  • REVIEWS, PRODUCT

Swanson Health started in 1969 in Fargo, ND with a mission to offer pure and potent health products at a great value. Nearly 50 years later, we continue to innovate science-backed vitamins and supplements, delivering wellness solutions that help people live simply healthier together, and find vitality at any age. Click here to learn more about us.

For nearly 50 years, Swanson Health's research and development team has delivered science-backed health and wellness products to people around the world. Our innovation is guided by clinical research, scientific consensus, emerging research and usage traditions, creating products that help you find vitality at any age. At Swanson, we don't hide our science behind proprietary formulas — we believe in easy-to-read, transparent labelling. What's printed on our labels, is exactly what you'll find in our products.

Swanson Health's purity and potency testing begins with our ingredient sourcing, continues through manufacturing, and goes beyond when a product hits the shelf. Our testing exceeds industry standards, ensuring each product meets our quality guarantees for purity and potency. Swanson facilities are Good Manufacturing Practices (GMP) certified, and we voluntarily participate in third-party, independent laboratory testing. With Swanson, you can be sure you're getting the most pure and potent health products at a great value. Click here to learn more about our quality standards.

®

Easy Refill

  • Get your favorite products delivered automatically
  • 10% off future orders of Swanson brand products in your subscription
  • FREE standard shipping on all future orders over $50
  • Control the frequency, delivery date, item quantity... or cancel at any time
  • Email reminders before each delivery
See all FAQs here