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SAM-e 400

Item: JR041

  • Supports mood and brain function

  • Helps detoxify the liver

  • Promotes healthy connective tissue

400 mg 30 Tabs

Retail $39.95
Save 38%
In Stock

Supplement Facts

Serving Size 1 Tablet

Servings Per Container 30

  Amount Per Serving %Daily Value
S-Adenosyl Methionine(from 800 mg of SAM-e tosylate disulfate) 400 mg *

*Daily Value not established.

Other Ingredients: Cellulose, mannitol, glyceryl behenate, magnesium stearate (vegetable source), silicon dioxide, sodium starch glycolate, enteric coating (methacrylate copolymers), magnesium silicate, titanium dioxide, triethyl citrate, riboflavin, glyceryl palmitostearate, and medium chain triglycerides.

USAGE: Take 1 tablet per day on an empty stomach or as directed by your qualified health care consultant.

WARNING: Individuals using prescribed medications such as antidepressants, including Selective Serotonin Re-Update Inhibitors (SSRIs) and MAO Inhibitors should consult a physician before using. Individuals with Parkinson's disease, bi-polar disorder or manic depression should not use SAM-e.

Jarrow FORMULAS® SAM-e 400 is foil blister-packed to maximize stability and safety. DO NOT use if outer seal of blister pack is broken.

Store in a cool, dry place. Keep out of the reach of children.

  • Suitable for vegetarians/vegans.
  • No wheat, no gluten, no soybeans, no dairy, no egg, no fish/shellfish, no peanuts/tree nuts.

Shipping Weight

.14 lbs

  • Supports mood and brain function

  • Helps detoxify the liver

  • Promotes healthy connective tissue
SAM-e (S-Adenosylmethionine) is an amino acid derivative that has undergone dozens of trials involving thousands of patients and has been clinically proven to benefit brain and joint function. Found in all living cells, SAM-e is also called activated methionine (an essential amino acid) since it is formed by the combining of ATP with methionine. SAM-e 400 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product. It is made naturally by microbiological fermentation and then specially processed to preserve 68-80% (S,S) SAM-e, the highest active level available.

Terms and Ingredient Definitions

Jarrow Formulas, Inc. SAM-e 400 Reviews

Summary of Customer Ratings & Reviews

Customer Ratings & Reviews

SAM-e 400 is rated 4.5 out of 5 by 21.
Rated 3 out of 5 by from I really can't tell if this product is doing anything or not. Maybe it takes a few months as sometimes supplements need. I will try it again for the fourth time.
Date published: 2015-04-15
Rated 5 out of 5 by from Great Product I have tried various brands of SAMe in the past. I find this brand to be the most effective for me.. Its quite expensive but worth the extra dollars. Give it a shot and see if you like
Date published: 2014-05-15
Rated 5 out of 5 by from SAM-e My stepfather told me about SAM-e many years ago. I've been using SAM-e 400 ever since. I like the bubble-pack style packaging - makes dosing easier and keeps the tablets whole.
Date published: 2014-02-17
Rated 5 out of 5 by from great product This product works great for me and the price is really good. (40.00 retail at local store)
Date published: 2013-06-24
Rated 5 out of 5 by from Jarrow Sam-E 400 Excellent product. I can really feel the difference in my state of mind.
Date published: 2013-06-09
Rated 5 out of 5 by from Jarrow Formulas, Inc. SAM-e 400 Very good product, I have also tried swanson's brand and it works just as well, but is cheaper.
Date published: 2013-03-31
Rated 5 out of 5 by from effective! I am very suprise about the effectiveness of this product mainely for liver fonction.
Date published: 2013-03-18
Rated 5 out of 5 by from Wonderful I have been taking Jarrow Sam E for 8 months now. It has truly lived up to it's claims. It's so good to know that I am taking something that is good for me in so many areas and helps my mood, too. You can't ask for more that that!! I would highly recommend it!
Date published: 2013-03-13
Rated 5 out of 5 by from Sam E 400 This is a great product. It really works.
Date published: 2013-03-09
Rated 5 out of 5 by from Best I've Ever Tried This product works better than anything I have tried in the past. With no digestive upset, it increases my joint mobility and enables me to move comfortably.
Date published: 2013-02-15
Rated 1 out of 5 by from beware - mannitol Specifically ordered this Jarrow, as online label showed no mannitol, which is tough to find. Product arrived and first ingredient on the label is mannitol! First time that's ever happened w/ Swanson though - so will try again.
Date published: 2012-11-10
Rated 5 out of 5 by from
Date published: 2012-10-24
Rated 5 out of 5 by from SAM E For Life This is a great SAM E. Joints feel better, digestion is better. There is a reall result in the GI track but it is not harsh. I am on this ine fire life!
Date published: 2012-04-19
Rated 5 out of 5 by from Great product & price I have taken SAM-e 400 for several years ... Swanson has the best product for the best price! Thank You!
Date published: 2012-04-01
Rated 1 out of 5 by from Didn't like If you have a problem getting a pill down. This pill is like a horse pill. Plus, it's very hard. I tired grinding it up, but even then, it left a real bad film on my teeth. I had to switch to a liquid. I ended up throwing most of the pills away.
Date published: 2011-02-12
Rated 5 out of 5 by from Regular Purchase I purchase the Jarrow Formula SAM-e 400 on a regular basis from Swanson, I love the product. My daughter and I take one tablet each day, so we buy a few boxes in each shipment. We appreciate the lower price by comparison to the stores here.
Date published: 2010-09-26
Rated 5 out of 5 by from Good product Great product and packaging.
Date published: 2010-05-16
Rated 5 out of 5 by from Really helps my mood Recently I read a book that talked about SAM-e, so I decided to try it. One thing I need to be aware of is the ingredients, as I have multiple food allergies and this Jarrow brand was the only one I could have. I have been on it for about a month and I can definitely tell a difference. It's a subtle, but noticeable, elevation in my mood. And the effect seems to be cumulative, as I experience fewer highs and lows in my overall mood. The book did mention that when you start SAM-e, you might notice a slight headache, which I did but it is gone now. It's nice to be more balanced, especially when life isn't!
Date published: 2010-02-14
Rated 5 out of 5 by from Joint Relief Got this Jarrow's by mistake. Glad it happened. Not all Sam-e products are equal. This one by Jarrow worked incredibly quick and the relief was amazing. I will continue to get this.
Date published: 2010-01-22
Rated 5 out of 5 by from Great Product SAM e definitely helps lift my mood and gives me a general all over good feeling. I have used SAM e for more than a year, and will continue to use it as needed. Overall rating: Excellent.
Date published: 2009-02-06
Rated 4 out of 5 by from mood enhancer My husband has responded very well to this product. We've both been taking SAM-e for it's multiple benefits, but my husband has definitely noticed it's mood-enhancement feature!!! Nice!
Date published: 2009-01-18
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Lee Swanson, Founder of Swanson Health Products

Risk-Free Purchase Guarantee on Jarrow Formulas, Inc. SAM-e 400

If you are dissatisfied for any reason, we'll give you a full refund and pay return shipping.

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© 2017 Ratings based on results of the 2017 Survey of Supplement Users. More information at
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