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In the review, researchers performed a meta-analysis of the pooled data from ten trials, in which healthy adults were given a daily multivitamin supplement or placebo for one month or more and changes in cognitive function were measured. The multivitamins varied among the studies, but in general they had some combination of B-complex vitamins and small amounts of other nutrients such as minerals, antioxidants, and herbal extracts.
The report noted the following findings:
The researchers found that there was not enough data looking at the effects of multivitamins on general cognition, reasoning, or mental speed to demonstrate clear benefits.
“Based on the evidence, it appears that multivitamin supplements may be useful in improving free recall memory in healthy adults,” said lead study author Dr. Natalie Grima of Monash University in Clayton, Australia. “Given that the recall of recently learned information is a core clinical feature of probable Alzheimer's disease, future research should investigate the effects of multivitamins in those diagnosed with Alzheimer's disease."
(J Alzheimers Dis 2012;29:561–9)
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