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NOW Foods


3.3 out of 5 (4)


Item: NWF224

  • Nervous system support

  • Supports emotional well-being

  • Vegetarian formula

400 mg 30 Tabs

Retail $45.99
In Stock
  • Nervous system support

  • Supports emotional well-being

  • Vegetarian formula
SAMe (S-adenosylmethionine), a compound native to the body, is a critical component of many biochemical reactions, including those that affect brain biochemistry and joint health. Numerous studies have indicated that SAMe can help to temporarily alleviate minor joint discomfort resulting from overexertion or stress. In addition, because SAMe is also necessary for the synthesis of neurotransmitters, it plays an important role in mood support. NOW SAMe is enteric-coated, which makes it very well tolerated and protects it from degradation. Contains no sugar, salt, yeast, wheat, gluten, soy, milk, egg, shellfish or preservatives.

Terms and Ingredient Definitions

Supplement Facts

Serving Size 1 Tablet

  Amount Per Serving %Daily Value
SAMe (S-Adenosyl-L-Methionine) (from 800 mg of S-Adenosyl-L-Methionine Disulfate Tosylate) 400 mg *

*Daily Value not established.

Other Ingredients: Cellulose, croscarmellose sodium, methacrylic acid, magnesium stearate (vegetable source), silica, triethyl citrate, stearic acid (vegetable source), citric acid and ascorbic acid.

Suggested Usage: As a dietary supplement, take 1 tablet daily, preferably on an empty stomach. Refrigeration recommended after opening.

WARNING: Individuals with bipolar (manic) depression should not take SAMe unless under professional medical supervision.

Contains no: sugar, salt, yeast, wheat, gluten, soy, milk, egg, shellfish or preservatives. Vegetarian/Vegan Product.

Shipping Weight

.38 lbs

Summary of Customer Ratings & Reviews

Customer Ratings & Reviews

Rated 3.3 out of 5 by 4 reviewers.
Rated 2 out of 5 by Swanson changed label directions Just received my NOW SAMe bottles -- I ordered two thinking they would last two months based on the suggested dosage shown in "two" places on the Swanson website, (one according to the label directions on Swanson!) Instead of the "one" tablet, the actual NOW bottle label says, "TAKE ONE TABLET TWO TO FOUR TIMES DAILY" -- a 30 bottle supply won't even last 10 days if I follow the directions closely. RIDICULOUS! They're headed back to Swanson's. January 6, 2016
Rated 5 out of 5 by Ingredients This is only 1 of 2 SAMe products I've found that has acceptable ingredients. NOW is a great company and I'm happy they've kept this product quality where all others (except for 1 company) have gone the way of artificial colors or titanium dioxide. January 11, 2014
Rated 1 out of 5 by SAME-E Your leafs and the fact you have to fill them all in is not a very good rating system. Convenience and Value and Quality are irrelevant to my experience. This was not the vitamin for me. It made me feel very heavy and foggy. May 28, 2010
  • 2016-05-26 T13:07:48.672-05:00
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Lee Swanson, Founder of Swanson Health Products

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