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Item: LE384

  • An amino acid derivative normally synthesized in the body

  • Facilitates glutathione usage and maintains acetylcholine levels

  • Helps maintain stable mood and joint function

400 mg 30 Tabs

Retail $36.00
Save 25%
In Stock
  • An amino acid derivative normally synthesized in the body

  • Facilitates glutathione usage and maintains acetylcholine levels

  • Helps maintain stable mood and joint function

In 2002, an agency within the U.S. Department of Health and Human Services conducted a meticulous evaluation of SAMe (S-Adenosyl-Methionine). Its findings show the efficacy of SAMe in helping to maintain stable mood and joint function without any side effects. In addition, SAMe has multiple mechanisms of action that are used throughout the body, especially in the liver, which help maintain liver health. SAMe facilitates healthy methylation enzymatic processes and boosts hepatic levels of the critical antioxidant glutathione. When glutathione is depleted it can lead to free radical damage. Life Extension's SAMe delivers 400 mg per tablet for optimum support.

Terms and Ingredient Definitions

Supplement Facts

Serving Size One Enteric Coated Tablet

  Amount Per Serving % Daily Value
S-Adenosyl-Methionine 400 mg **

**Daily value not established.

Other Ingredients: cellulose, mannitol, hydroxypropyl methylcellulose phthalate, citric acid, silica, stearic acid, silica, glyceryl triacetate, sodium starch glycolate, croscarmellose sodium, titanium dioxide, yellow ochre.

DIRECTIONS: Take one (1) tablet two to three times daily in divided doses, preferably on an empty stomach, or as recommended by a healthcare practitioner. Take with co-factors vitamins B12, B6, and folic acid.

CAUTION: SAMe should not be taken by those diagnosed with bipolar disorder.

Store in a cool, dry place.


  • Do not purchase if foil is broken or damaged.
  • When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Shipping Weight

.13 lbs

Life Extension SAMe Reviews

Summary of Customer Ratings & Reviews

Customer Ratings & Reviews

Why Shop Swanson® Brands?

"With my personal 100% money-back satisfaction guarantee, you have nothing to lose and great savings to gain."

Lee Swanson, Founder of Swanson Health Products

Risk-Free Purchase Guarantee on Life Extension SAMe

If you are dissatisfied for any reason, we'll give you a full refund and pay return shipping.

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