$4.99 Standard Shipping! See details
Free Shipping Icon


America's #1 Rated
Catalog/Internet Brand
Based on Customer Satisfaction
For Help or to Order 1-800-824-4491 Call or Chat
Eco Catalog
  1. Swanson Health Library
  2. Health Concerns
  3. Women's Health

Lee Swanson Research Update

Study ‘Leaves Little Doubt’ About Pycnogenol’s Benefits for Menopause Symptoms

February 21, 2013

Daily supplements of extracts from the bark of French Maritime Pine may help reduce the symptoms of menopause like hot flashes and night sweats, says a new study.

Twelve weeks of supplementation with Pycnogenol® were associated with significant reductions in scores of menopause symptoms, as measured by the Women’s Health Questionnaire (WHQ) and the Kupperman index, according to findings published in The Journal of Reproductive Medicine.

Pycnogenol—a combination of procyanidins, bioflavonoids and organic acids extracted from the bark of the maritime pine—is included in more than 700 dietary supplements, cosmetic products and functional foods and beverages worldwide.

The ingredient has been the subject of scores of clinical studies suggesting benefits covering everything from cardiovascular, joint, cognitive and eye health to the relief of hay fever, PMS, tinnitus, hemorrhoidal pain and menopause symptoms.

“These findings leave little doubt about the benefit of Pycnogenol for women interested in controlling climacteric symptoms with a more natural approach. Our study is the first to provide evidence for the safety and efficacy of Pycnogenol in perimenopausal women,” said Takafumi Kohama, lead researcher from Keiju Medical Center in Japan.

Perimenopause, the transition that women experience leading into menopause, lasts an average of four years and is marked by a number of uncomfortable symptoms including hot flashes, insomnia, night-time sweating, palpitations, depression, anxiety, and memory problems.

The researchers—Takafumi Kohama, MD, and Masako Negami, MD—recruited 170 perimenopausal women to participate in their randomized, placebo-controlled, double-blind, parallel-group clinical trial. The women were randomly assigned to receive either daily Pycnogenol supplements (60 mg per day) or placebo for 12 weeks.

Results showed that there were no statistically significant differences between the groups for estradiol, follicle stimulating hormone, insulin-like growth factor, IGF binding protein 3, and dehydroepiandrosterone, which meant there were no hormonal effects of Pycnogenol, said the researchers.

A significant placebo effect was observed, said the researchers. Compared to baseline values, the Pycnogenol group exhibited significant improvements in all symptoms with the exception of formication [crawling skin] sensation and abnormal perceptions. The pine bark extract was also found to be especially effective for improving vasomotor and sleep problems/insomnia symptoms.

According to the study, the total symptom improvement using the Kupperman index, which is said to represent the most commonly utilized questionnaire in Japan, was statistically significant versus the placebo group.

“This study, applying a relatively low daily dose, allows identification of those climacteric symptoms which respond particularly well to supplementation with Pycnogenol,” concluded the researchers.

The study was run independently and was not affiliated with Horphag, the company behind Pycnogenol.

The Journal of Reproductive Medicine 2013 (58): 39-46

New to Natural Health?
  • Text Resize: A  A
  • Email this pagePrint
  • Bookmark and Share
Customer Service
  • Live Chat
    (8am-11pm Central Time daily)
  • Call Us
  • Para Ordenes en Español
  • 1-800-254-1885
Loco for Coco?

Need help? Call Us Now

We Accept
  • Visa
  • MasterCard
  • AmEx
  • Discover
  • JCB
  • Diners Club
  • PayPal

Secured by Entrust

Eco Catalog

†Ratings based on results of the 2015 ConsumerLab.com Vitamin and Supplement Users Survey. More information at www.consumerlab.com/survey2015.

Notice: The products and information found on www.swansonvitamins.com are not intended to replace professional medical advice or treatment. These statements have not been evaluated by the Food and Drug Administration. Our dietary supplements are not intended to diagnose, treat, cure or prevent any disease or medical condition. Individual results may vary. SwansonVitamins.com urges you to seek the advice of a qualified professional for any health concern lasting more than two weeks, and to share with your provider any information pertaining to your health and well-being, including the use of supplemental nutrition. Read complete terms of service.

© 2015 Swanson Health Products

close popup
No Thanks

Your 10% Off Promo Code is on the Way! Thanks for signing up for emails.

You're now signed up to receive exclusive deals and savings opportunities!

Thanks again for connecting with us. Keep an eye on your inbox — your first coupon is on its way!

Thank You! This email address is already signed up

You are signed up for the following:

  • Offers
  • Recipes
  • E-Newsletter
  • Updates & Reminders

Thank you for your interest and be assured that you will continue to receive our emails at this address.

Look for your next communication from us within the next week.


We are having trouble processing your request.

Our apologies!

Please try again later.