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“A 16-week dietary supplement of soluble fiber in overweight or obese patients was well tolerated, induced satiety and had beneficial effects on some cardiovascular disease risk factors, the most important of which was a significant decrease in plasma LDL cholesterol concentrations,” a study published in the British Journal of Nutrition stated.
The researchers, led by Jordi Salas-Salvado from Saint Joan University Hospital in Reus, Spain, randomly assigned 200 overweight or obese patients to receive either a mixed fiber dose (three grams of psyllium seed husk and one gram of glucomannan) twice or three times a day, or placebo for 16 weeks. The study was a parallel, double-blind, placebo-controlled clinical trial.
At the end of the study, the researchers reported that weight loss “tended” to be higher in both fiber groups (4.52 and 4.60 kg lost in the twice- and three-times-a-day group, respectively), compared to the placebo group (0.79 kg lost). In addition, satiety (a feeling of fullness) was reported to be increased after consuming the fibers.
Moreover, LDL cholesterol levels—a cardiovascular risk marker—decreased by 0.38 and 0.24 mmol/l in the twice- and three-times-a-day group, respectively, compared to a decrease of only 0.06 mmol/l in the placebo group, the authors stated. Improvements in the ratio of total cholesterol to HDL cholesterol and HDL to LDL were also reported.
British Journal of Nutrition 99:1380-1387, 2008