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Lee Swanson Research Update
Resveratrol Shows Metabolic Benefits for Obese Persons
October 2010
Daily intakes of resveratrol, a compound from red wine, may improve the metabolic profile of obese people, according to a new study from Denmark.
Writing in the International Journal of Obesity, researchers from Aarhus University report that resveratrol changed the production of certain compounds called adipokines from human fat cells and produced an anti-inflammatory effect.
The research is reported to be the first in vitro study to suggest resveratrol has anti-inflammatory effects on adipokine expression and secretion in human fat tissue.
"Small interfering molecules such as resveratrol are in this matter hypothesized to possess beneficial effects and might improve the metabolic profile in human obesity," wrote the researchers, before adding that the results need to be replicated in vivo.
The new study sought to investigate whether the compound’s anti-inflammatory benefits extended to the low-grade inflammatory state associated with obesity. This is "characterized by abnormal levels of circulating pro-inflammatory factors and an abnormal production of bioactive factors/adipocytokines from the adipose tissue," explained the researchers, and these adipocytokines are "suggested to have direct implications for the development of the metabolic syndrome."
Led by Jen Olholm from the Department of Endocrinology at Aarhus University Hospital, the researchers examined the effects of resveratrol on levels of adipocytokines—particularly interleukin 1beta (IL-1B)—in human adipose tissue explants.
When human fat cells were exposed to IL-1B, the researchers noted increases in the secretion of pro-inflammatory compounds, including IL6, IL8 and MCP-1. However, when the cells were simultaneously exposed to resveratrol, a 16% to 36% reduction in the expression of these cytokines was observed.
"Our results show that resveratrol ameliorates the pro-inflammatory response in human adipose tissue and increases adiponectin expression changes, which is hypothetically beneficial, as adipose tissue from obese individuals with metabolic syndrome expresses lower adiponectin levels and higher levels of pro-inflammatory adipokines," wrote the researchers.
International Journal of Obesity 34(10):1546-1553, 2010-10-12
