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Researchers reviewing articles about a wide variety of studies involving vitamins C and E have cited the exceptional safety of C and E supplementation. They point to the tolerable upper intake levels of 2,000 mg for vitamin C and 1,000 IU for vitamin E in adults as established by the Food and Nutrition Board of the Institute of Medicine. After observing many clinical trials researchers noted "no consistent pattern of adverse effects...at any intake" of the two vitamins. They concluded that vitamin C doses at less than 2,000 mg per day and vitamin E in amounts under 1,600 IU per day are safe for most adults.
American Journal of Clinical Nutrition 81(4):736-745, 2005