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Lee Swanson Research Update

Low Levels of B-6 Could Affect Parkinson’s Disease Risk

April 2010

Insufficient levels of vitamin B-6 may increase the risk of Parkinson’s disease by about 50%, says a new study from Japan.

The study, published in the British Journal of Nutrition, does not prove that low vitamin B-6 levels are the cause of Parkinson’s disease, but indicates that additional study should focus on whether increased levels of vitamin B-6 may reduce the risk of developing the disease.

On the other hand, blood levels of vitamin B-12, folate and riboflavin were not linked to the incidence of Parkinson’s disease.

Parkinson’s disease, named after Dr. James Parkinson, the London doctor who initially identified it as a particular condition, occurs when nerve cells are lost in a part of the brain called the substantia nigra.

The link between B-vitamin intake and Parkinson’s disease is related to homocysteine, an amino acid reported to be potentially toxic to brain cells.

The researchers conducted a hospital-based case-control study involving 249 people with Parkinson’s disease and 368 people without any neurodegenerative condition.

Intakes of the B vitamins were assessed using a validated, self-administered, semi-qualitative, diet questionnaire. After crunching the numbers, no link was found between PD and folate, vitamin B-12 or riboflavin. However, low intakes of B-6 were linked to an increased risk of the disease, independent of other factors, concluded the researchers.

British Journal of Nutrition Published online ahead of print

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