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Lee Swanson Research Update

Pectin Could Be Lethal to Prostate Cancer Cells

January 2003

A fiber derived from fruits and vegetables killed prostate cancer cells in an in vitro experiment, according to researchers from the University of Georgia at Athens Cancer Center.

In the experiment, researchers tested the effects of several types of pectin, including fractionated pectin powder (FPP), citrus pectin and pH-modified citrus pectin on androgen-responsive and androgen-independent prostate cancer cell lines. While FPP induced a 40-fold increase in apoptosis (cell death) compared with untreated cells, citrus pectin did not appear to have an effect until it underwent heat treatment.

"What this paper shows is that if you take human prostate cancer cells and add pectin, you can induce programmed cell death," according to associate professor Debra Mohnen, Ph.D. "If you do the same with non-cancerous cells, cell death doesn’t occur."

Glycobiology17(8):805-819, 2007

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