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Japanese researchers wanted to know how much influence DHEA (dehydroepiandrosterone) has on the body so they initiated a study. Their premise was "DHEA concentration decreases with age. There is evidence that DHEA has a protective effect against age-related disorders, including cardiovascular disease."
Researchers administered 25 mg of DHEA per day to 12 older men (mean age 54 years) and a placebo to 12 controls for 12 weeks. Epithelial function, a marker of arterial flexibility, improved in the DHEA-treated men after four weeks and these subjects also experienced significant reductions in blood-sugar levels without altered insulin levels.
The scientists concluded that "low dose DHEA supplementation improves vascular endothelial function and insulin sensitivity and decreases the plasminogen activator inhibitor type 1 concentration. These beneficial changes have the potential to attenuate the development of age-related disorders such as cardiovascular disease."
Journal of Clinical Endocrinology 88(7):3190-3195, 2003