Lee Swanson Research Update

Study Subjects See Improvement in Memory and More with Prevagen®

April 2010

The Prevagen Quality of Life Study showed a statistically significant improvement in memory among 56 participants.

Subjects consumed 10 mg of Prevagen daily in the open-label study. After only 30 days of the 90-day study 57% of participants had improvement in general memory, 51% in retaining information, 84% in remembering driving directions and 66% in word recall.

Over a 90-day period researchers measured changes in overall cognition, quality of sleep, energy, mood, pain and general health. Changes in performance were measured via a standardized battery of questions. The results of the study showed improved performance in all parameters.

The following are questions from the survey. The data reflects those who self-reported a "poor" memory Day 0. Poor memory is defined as the participant selecting an answer in the bottom half of possible choices when asked to evaluate their memory in specific areas.

Are you forgetful? Thirty-five participants out of 56 at Day 0 reported being occasionally, frequently or always forgetful. In this subpopulation, 23% reported an improvement at Day 8. Improvement is defined by the participant’s move up at least one answer selection choice, e.g. from "frequently" to "occasionally." By Day 60, 63% of the participants noted an improvement in memory.

Do you have trouble finding the words you want to say, finishing sentences or naming people or things? At Day 0, 39 participants indicated they had difficulty finding words always, very frequently, frequently or occasionally. A rapid improvement was seen by Day 8 with 67% of the participants reporting less cognitive impairment in conversation. At Day 30, the percentage reporting improvement increased to 85%. While there was a slight trend down from Day 60 (79%) to Day 90 (74%), this change represents a handful of subjects. A full three-quarters of the people saw a sustained improvement in their ability to recall words in conversation over the three-month period.

Do you need reminders to do things like chores, shopping or taking medicines? At Day 0, 26 participants indicated they had a significant need for reminders in their activities of daily living such as chores, shopping and taking medicines by answering always, very frequently, frequently, or occasionally. There is a noticeable benefit seen at Day 8 with 61% reporting less of a need for reminders. The improvement seen at Day 8 continued to increase throughout the duration of the study. At Day 90, 80% of the participants reported needing fewer reminders to conduct their routine activities.

Prevagen Quality of Life Study, Memory Loss Improvement Study QB-0011

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