Lee Swanson Research Update

Omega-3s Display Significant Antidepressant Effect in Study

November 2007

Calling for large scale trials to further verify their findings, researchers in Taiwan found "a significant antidepressant effect" with omega-3 polyunsaturated fatty acids (PUFAs).

Members of the Department of Psychiatry, Chang Gung Memorial Hospital-Kaohsiung medical Center, Chang Gung University College of Medicine in Kaohsiung, Taiwan initiated the study to find what role, if any, omega-3s play in people with depression.

"Evidence has indicated an association between depression and low dietary intake of omega-3 polyunsaturated fatty acids (PUFAs)," study authors reported. "The goal of this study is to systematically evaluate the antidepressant efficacy of omega-3 PUFAs" by conducting a meta-analysis (analyzing previous studies).

Researchers reviewed studies from 1966 through August, 2006 using the key words: depression, depressive disorder, or mood disorder; and omega-3, EPA (eicosapentaenoic acid), DHA (docosahexaenoic acid), polyunsaturated fatty acid, or fish oil. The analysis included 10 double-blind, placebo-controlled studies in patients with mood disorders receiving omega-3 PUFAs with the treatment lasting four weeks or longer.

When pooling the results of the 10 studies, researchers found a significant antidepressant effect with omega-3 PUFAs. Also, they found that omega-3 PUFAs significantly improved depression in patients with clearly defined depression or with bipolar disorder.

Journal of Clinical Psychiatry 68(7):1056-1061, 2007

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