Lee Swanson Research Update

High Homocysteine Levels may Play a Role in Cognitive Decline

October 2003

Reducing homocysteine concentrations in the blood by administering B-vitamin supplements "may provide some protection against cognitive decline" in the elderly population, according to a study in the American Journal of Clinical Nutrition.

In a trial on about 1,800 Hispanic subjects participating in the Sacramento Area Study on Aging, researchers found inverse associations between homocysteine concentrations and several indexes of cognitive function, including the global Modified Mini-Mental State Examination assessment and the picture association, verbal attention span, and pattern recognition tests.

Their findings fit in with previous evidence showing homocysteine to be a marker for deficiency of vitamin B-12 and folic acid. Homocysteine is also a well-documented risk factor for cardiovascular disease, and is related to both vascular dementia and Alzheimer's disease.

While researchers found that high homocysteine levels may have an influence on cognitive decline, they noted that demographic factors such as age and education are more strongly associated with cognitive scores than are homocysteine levels.

American Journal of Clinical Nutrition78(3):441-447, 2003

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