Lee Swanson Research Update

Vitamin E Could Play Role in Fighting Liver Disease

November 2010

More and more Americans are developing nonalcoholic steatohepatitis (NASH)—liver inflammation and damage caused by excess fat deposits.

There are no currently approved treatments for this condition, also known as fatty liver disease. But there is good news: vitamin E might help.

Researchers at the Saint Louis University Liver Center randomly assigned 84 adults with NASH and without diabetes to receive vitamin E at a dose of 800 IU daily and 83 subjects to receive a placebo for 96 weeks.

The primary outcome was an improvement in histologic features of NASH, as assessed with the use of a composite of standardized scores for steatosis, lobular inflammation, hepatocellular ballooning and fibrosis.

Vitamin E therapy, as compared with placebo, was associated with a significantly higher rate of improvement in NASH (43% vs. 19%). Serum alanine and aspartate aminotransferase levels were reduced with vitamin E as compared with placebo and vitamin E was associated with reductions in hepatic steatosis and lobular inflammation compared to placebo. There was however, no improvement in fibrosis scores with vitamin E.

New England Journal of Medicine 362:1675-1685, 2010

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