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Lee Swanson Research Update

Glucosamine Sulfate Preferred Over Acetaminophen For Knee Pain

October 2005

"Glucosamine sulfate at the oral once-daily dose of 1,500 mg might be the preferred symptomatic medication (compared to acetaminophen) in knee osteoarthritis," according to researchers from Spain and Portugal who initiated the Glucosamine Unum in Die Efficacy (GUIDE) Trial.

Three hundred eighteen patients (88% women) with knee osteoarthritis were randomized to receive either 1,500 mg per day of glucosamine sulfate, 3,000 mg per day of acetaminophen or placebo over a 24-week period to determine their effect on various pain and mobility indexes of osteoarthritis.

Researchers found that the efficacy of glucosamine sulfate compared to placebo was significant in all test indexes. Acetaminophen showed more activity than placebo, but failed to reach a significant difference on two of the test indexes, leading scientists to give a high recommendation for the use of glucosamine sulfate in treating knee pain caused by osteoarthritis

†Ratings based on results of the 2012 ConsumerLab.com Vitamin and Supplement Users Survey. More information at www.consumerlab.com.

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