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Lee Swanson Research Update

CLA Appears To Inhibit Cox-2, Helping Reduce Inflammation

January 2006

Researchers from the University of Wisconsin-Madison (UWM) say that one of the isomers from conjugated linoleic acid (CLA)—found in dairy products as well as dietary supplements—regulates the COX-2 protein, thus potentially reducing inflammatory disease.

A major determinant in comfortable joint and muscle function is the activity of the enzyme known as cyclooxygenase-2 (COX-2). To put it simply, the less COX-2 activity there is, the more comfortably your joints and muscles are able to work. Therefore, inhibiting COX-2 activity can be a priority when it comes to seeking relief for painful joints and muscles.

"It’s clear from previous research that conjugated linoleic acid, or CLA, prevents inflammatory damage resulting from immune response," said Mark Cook, professor of animal science at UMW. "We’ve identified the biochemical mechanism by which this occurs." That mechanism appears to be the 10-trans, 12cis form of CLA, which inhibited COX-2 protein expression by 80% in the UMW study.

Journal of Lipid Research 46(10):2134-2142, 2005

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