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Lee Swanson Research Update
Study Validates Maitakegold 404's Superior Immunostimulating Properties
December 2005
MaitakeGold 404 mushroom glucan extract scored high in immune system support in a study published in the Journal of the American Nutraceutical Association.
Researcher and study author Dr. Vaclav Vetvicka of the University of Louisville compared the immunostimulating properties of two different maitake mushroom glucan extracts, one being MaitakeGold 404, against Lentinan, a pharmaceutical that contains a standard, well-researched mushroom-derived glucan. Lentinan has been used clinically for immunotherapy in Japan for over 25 years and is considered the benchmark of mushroom-derived glucans. The study showed that MaitakeGold 404, when compared to the other maitake extract and Lentinan, had the highest level of stimulation in the greatest number of immune categories tested.
In the study, MaitakeGold 404 via oral administration caused direct stimulation of cells involved in immune reactions as well as the release of numerous cytokines necessary for immune response and defense. MaitakeGold 404 was shown to be effective even in relatively small doses compared to the other tested agents.
The research demonstrates that maitake extracts used as dietary supplements, in particular MaitakeGold 404, provide a generally high level of immune stimulation, are relatively more biologically and immunologically active than Lentinan and maintain their biological activity when administered orally.
Patented MaitakeGold is currently being used exclusively in a multi-phase U.S. Government-funded clinical trial at Memorial Sloan Kettering Cancer Center and is also being evaluated in a five-year study at Memorial Sloan Kettering, along with other botanical agents, assessing their immunomodulation activity.
