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Lee Swanson Research Update
Gingerol Appears to Destroy Pancreatic Cancer Cells
April 2007
Gingerol, a natural component of the herb ginger, inhibits cell growth and induces cell death in human pancreatic cancer cells, according to Korean researchers reporting their study results in Yonsei Medical Journal.
Researchers noted that "gingerol, a major phenolic compound derived from ginger, has anti-bacterial, anti-inflammatory and anti-tumor activities. While several molecular mechanisms have been described to underlie its effects on cells in vitro and in vivo, the underlying mechanisms by which gingerol exerts anti-tumorigenic effects are largely unknown. The purpose of this study was to investigate the action of gingerol on two human pancreatic cancer cell lines."
The scientists incubated the two separate pancreatic cancer cell lines with varying concentrations of gingerol for different durations. They found that cell growth was inhibited in direct relation to the dose and duration of gingerol application. Gingerol interfered with the cell-growth cycle in both cell lines and hastened cell death in one of the cell lines.
Most important, gingerol killed cancer cells that carry a mutation in a gene known as p53, which is mutated in more than half of human cancers and can contribute to resistance to radiation and chemotherapy. In view of its beneficial effects, gingerol may eventually be used to facilitate tumor response to treatments for pancreatic cancer.
Yonsei Medical Journal 47(5):688-697
