Lee Swanson Research Update

Cranberry Compounds May Block Cancer Development

December 2005

Compounds occurring in cranberries may help fight metastasis, or the development of cancer cells, researchers in Massachusetts reported.

The chemicals, called proanthocyanidins (PACs), were found to inhibit the growth of human lung, colon and leukemia cells in vitro, without affecting healthy cells. The study was reportedly among the first to examine the anti-cancer potential of cranberries, which are recognized for their role in addressing urinary tract infections.

"Unlike most fruit, cranberries contain PACs with A-type linkages between units, a structural feature identified in cranberry PACs with antibacterial adhesion properties," wrote Catherine Neto, Ph.D., assistant professor of chemistry and biochemistry at the University of Massachusetts-Dartmouth, and her colleagues. "Previously published reports have suggested that cranberry PACs have anti-cancer properties but there are few data on tumor growth inhibition by well-characterized cranberry PACs."

The recent study stated, "In vitro growth inhibition assays in eight tumor cell lines showed that selected fractions (of cranberry PACs) inhibited the growth" of lung tumors, colon and leukemia cells.

Journal of the Science of Food and Agriculture 86(1):18-25, 2005

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