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L-carnitine appears to work better the longer one takes it. In a rat model, researchers gave 28 mg/kg/d of L-carnitine the last four weeks of a six-week moderate-intensity training program. L-carnitine supplementation increased time to exhaustion, similar to that for trained rats, and the effect was seen to be even greater in the supplemented, trained rats. The most interesting find was that the best impact in trained rats was after three weeks of supplementation.
Nutrition 19(4):337-341, 2003