Lee Swanson Research Update

Tocomin® Tocotrienols Protect Against Stroke-induced Neurodegeneration

October 2005

Tocomin

A study conducted at the Ohio State University Medical Center and funded by the National Institutes of Health confirms earlier studies suggesting that Tocomin natural full-spectrum palm tocotrienol complex protects against stroke-induced neurodegeneration.

In the study, published in the American Heart Association's journal Stroke, Tocomin showed significant protection against stroke-induced injury compared with matched controls.

Researchers supplemented spontaneously-hypertensive rats with Tocomin tocotrienol complex. The animal model chosen for the trial is commonly used in stroke research as hypertension represents one of the major risk factors of stroke.

Rats supplemented with Tocomin benefited from more protection against stroke-induced injury compared to unsupplemented controls. The neuroprotective effect was associated with suppression of stroke-associated c-Src activation, which is a key mechanism that contributes to neurodegeneration. Researchers also found that tocotrienols helped protect against cell death.

Stroke 36(10):e144-e152, 2005

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