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Lee Swanson Research Update
CPC-choline (Citicoline) Appears to Increase Energy in Brain Cells
Supplements of CPC-choline may boost biological energy in brain cells, according to the results of a study presented recently at the Society for Neuroscience 37th annual meeting in San Diego, CA.
The study used Cognizin Citicoline and found significant increases in the brain’s energy sources in 16 men who took the supplement for six weeks.
“This study looked at the effect of Cognizin Citicoline or CDP-choline on the brain’s energy sources,” said researcher Perry Renshaw, M.D., Ph.D. from Harvard Medical School. “As we age, the brain’s efficiency diminishes. Caffeine affects the whole brain, but Cognizin delivers nutrients to only the regions of the brain that sustain your ability to pay attention, make good decisions, and provide a sense of direction enabling you to get work done.”
Citicoline is sold as a dietary supplement in North America. Under structure/function claims allowed under DSHEA, research currently supports its use “for improvement of memory and general cognitive function.” The new study supports the claims, finding that self-administration of either 500 mg or 2,000 mg of the ingredient led to significant increases in the brain’s energy sources, regardless of dose.
The researchers found increases in the levels of nucleoside triphosphate (NTP) in the anterior cingulated portion of the brain, “primarily reflecting levels of ATP and phosphocreatine, reflecting the high energy phosphate buffer stores,” study authors wrote.
“These data demonstrate that citicoline-related alterations in brain neurochemistry are regionally specific and suggest that oral citicoline administration improves cellular bioenergetics of the anterior cingulated cortex,” researchers said. “These findings have important implications, given that maintenance of phosphocreatine and beta NTP levels have been shown to be neuroprotective.”
Society for Neuroscience 37th Annual Meeting, Session 301
