Spearmint Phenolic Complex with Neumentix
Concentrated Support for Memory and Cognitive Function
Chad M. Cook, Ph.D., is a Senior Scientist leading metabolic and nutrition clinical trials at the Biofortis Research Center. Dr. Cook has most recently provided technical and scientific leadership in the design of clinical trials to study the effects of different dietary supplements, including the spearmint extract discussed in this article, on cognitive function and safety/tolerability outcomes. Dr. Cook holds a B.S. in Exercise Physiology, M.S. in Human Nutrition, and Ph.D. in Nutritional Sciences.
SWANSON: To start off, could you explain briefly, what is Neumentix?
DR. COOK: Neumentix is a proprietary spearmint phenolic complex, standardized to provide consistent levels of rosmarinic acid and total phenolics, which has been shown to improve certain aspects of cognitive function in older individuals with self-reported memory impairment.
SWANSON: You mentioned rosmarinic acid—could you tell us more about it; its biological activity and implications for our health?
DR. COOK: Rosmarinic acid is a phenolic compound first isolated in 1958 from rosemary, from which it gets its name. It is found in many culinary herbs from the order Lamiales, including basil, marjoram, sage, thyme and mint, with spearmint being a particularly rich source. In plants, it acts as a defense compound against insects and microbes. Results from preclinical studies conducted by scientists at Kemin Industries, Inc. suggest it has antioxidant activity and can affect neurochemistry through its influence on certain neurotransmitters, such as acetylcholine. However, these effects have not been studied in humans.
SWANSON: How is Neumentix different from other spearmint extracts?
DR. COOK: Well, it’s a combination of factors, including the quality of the spearmint used as source material and the processing techniques used to produce the extract. According to scientists at Kemin Industries, Inc., Neumentix is derived from select lines of non-GMO spearmint specially developed to produce high levels of rosmarinic acid and other water-soluble phenolic compounds—far more than found in ordinary, commercially cultivated spearmint. The spearmint is quick dried immediately after harvest using state-of-the-art dehydration technology to preserve its full phenolic profile. The mint is then processed through specialized water-based extraction techniques to produce a concentrated phenolic complex with standardized levels of total phenolics and rosmarinic acid, the constituents believed to be most beneficial for cognitive support.
Most conventional spearmint extracts—the extracts used as flavoring for baked goods, like you find in the grocery store—are made using alcohol as a solvent, because they’re focused primarily on concentrating the flavorful essential oils, which are only minimally soluble in water. Neumentix, aside from being alcohol free, delivers higher concentrations of water-soluble phenolics than ordinary mint extracts.
SWANSON: Neumentix has recently undergone testing in human clinical trials. Could you give us an overview of their findings?
DR. COOK: It appears to have benefits for memory, mood, sleep, and concentration/attention; the latter of which may suggest a benefit for mental focus. In one 30-day open-label trial involving 50- to 70-year-old men and women with selfreported memory impairment, 900 mg of Neumentix per day improved attention, working memory and executive function (Figure 1).
In a 90-day randomized, placebo-controlled trial involving 50- to 70-year-old men and women with age-associated memory impairment, people taking 900 mg of Neumentix per day showed significant improvement in working memory (Figure 2) and reported that they got to sleep faster at night compared to people taking a placebo. There was also a trend toward decreases in total mood disturbances and improved vigor in subjects taking Neumentix.
SWANSON: With an herbal extract as concentrated and potent as Neumentix, safety and side effects are always potential concerns. What’s its safety record?
DR. COOK: Neumentix also demonstrated an excellent safety profile and was well tolerated in human clinical trials at intakes as high as 900 mg per day, with no gastrointestinal disturbances or stomach discomfort.
Neumentix is a trademark of Kemin Industries, Inc.